Sentence examples for molecular patterns released from inspiring English sources

Furthermore, both DNA and uric acid are damage-associated molecular patterns, released during cell death to signal danger and trigger inflammation.

ROS also plays a role in the activation of the inflammasome, an important arm of the innate immune defense, whereby pattern-recognition receptors on host cells identify danger to the host, via recognition of pathogen-associated molecular patterns from microbes and damage-associated molecular patterns released from injured tissue (Bauernfeind and Hornung 2013).

In a recent work, Fang et al, demonstrate that danger-associated molecular patterns, released from chemically (oxaliplatin and/or 5-fluorouracil) stressed CRC cells, can induce mouse and human DC activation and maturation via TLR4 and enhance the induction of an anti-tumor T-cell immune response both in vitro and in vivo.

TLR4 is an important innate immune receptor that recognizes pathogen-associated molecular patterns (e.g., lipopolysaccharide), as well as endogenous danger-associated molecular patterns released in response to cellular distress (e.g., DEP-induced hyaluronan or high-mobility group box 1) (Bianchi 2007).

It is these DAMPS (which are also contributed to by nuclear DNA, purine metabolites, as well as other nuclear and cytosolic proteins), that stimulate an acute phase response by the innate immune system which is biologically concordant with pathogen-associated molecular patterns released during infection.

Thus, the immune response against tumor cells via IFN-γ release or stimulation of TLR by pathogen-associated molecular patterns (PAMP) released by microorganisms may actually promote tumor growth by inducing B7-H1 expression, which then inhibits CTLs.

Macrophages are activated and modulated by cell debris and molecules bearing the damage-associated molecular patterns (DAMPs) released by injured cells, and by cytokines present in the specific immuno-microenvironment during CKD (Williams et al., 2010).

Intracellular danger-associated molecular patterns (DAMPs) released during cell death can activate cytoprotective responses by engaging receptors of the innate immune system.

Endogenous danger-associated molecular patterns (DAMPs) released from necrotic cells activate caspase-1 through an NLRP3-inflammasome.

NAPL3 on the other hand responds to so-called danger-associated molecular patterns (DAMPs) released during cellular necrosis, such as uric acid crystals [ 49].

These receptors recognise conserved pathogen associated molecular patterns (PAMPs) released from or found on the surface of pathogens [ 2], and result in the activation of responsive cells.