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Toll-like receptors (TLRs) are a family of innate immune receptors that recognize molecular patterns associated with microbial pathogens (PAMP), and induce antimicrobial immune responses.
Using a combined approach to analyse the molecular patterns associated with the DSS-gene signature, we provide an integrative overview of the transcriptional responses altered in DSS children.
Whereas TLRs are critical for detecting molecular patterns associated with microbial pathogens [16] [20], IL-1 receptor (IL-1R1) is important for amplifying inflammatory responses triggered by microbial pathogens [21].
TLRs act as sensors that can recognize several molecular patterns associated with viruses including surface glycoproteins (TLR1, 2 and 4) [1]–[3] and nucleic acids (TLR3, 7, 8 and 9) [4]–[7].
We took advantage of some of these available mitogenomes and compared them in an evolutionary framework, searching for putative molecular patterns associated to the annual life style.
The PRRs can efficiently detect viral infections through recognition of molecular patterns associated with viral genomes and replication products [ 3– 5].
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This study aims to investigate whether a systemic molecular pattern associated with aging (senescent-associated secretory phenotype [SASP]) is elevated in adults with late-life depression (LLD), compared with never-depressed elderly comparison participants.
To pursue investigations on the role of RIPK1 during viral hepatitis, we exposed Ripk1LPC-KO and Ripk1fl/fl mice to a molecular pattern associated with viral infection, the poly I C.
Since, in contrast to T- and B- cells, DC are not antigen specific, DC-based assays do not measure antigen-specific responses but rather the response to pathogen associated molecular patterns (PAMP) associated with the vaccine (components).
We hypothesized that the carotid body, a tissue of neural crest origin, detect pathogen associated molecular patterns and danger associated molecular patterns via an inflammasome-dependent mechanism similar to that described in immune cells.
In addition, these S INDELs and the associated SNPs in the hypervariable S1 region of the S gene may represent a stable molecular pattern possibly associated with a less virulent phenotype.
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