Sentence examples for molecular pathways with from inspiring English sources

In this framework, individual targets are replaced by molecular pathways with phenotypic, or cell-based, responses [1] as the optimization targets.

ALS shares altered molecular pathways with other neurodegenerative diseases, such as Alzheimer's, Huntington's, and Parkinson's diseases.

Notably, this method also means that each miRNA can modulate several molecular pathways with potentially unpredictable side effects.

This network suggested the possibility that five OsWD40 genes might play roles in different molecular pathways with the participation of four MADS-box genes.

We mapped the differentially expressed genes in the varying grades of CAN/IFTA to molecular pathways with a special emphasis on established growth factor and integrin signaling pathways.

Inhibiting multiple molecular pathways with biologic therapies is an attractive treatment strategy for cancer [ 3] and currently under investigation for R/M-SCCHN [ 4].

The results indicate that the decreasing frequency of FGFR3 mutations in patients with higher tumors stages is caused by the emergence of tumors following a different molecular pathway with no FGFR3 mutations but with presence of CIS.

For example, Zhan and Yeung modeled a molecular pathway with the following ODEs [ 34]: (1) x ˙ (t ) = f (x (t ), u (t ), θ ), x (t 0 ) = x 0, y (t ) = g (x (t ) ) + η (t ), where x ∈ R n is the state vector of the system, θ ∈ R k is a parameter vector, u(t) ∈ R p is the system's input, y ∈ R m is the measured data, η(t) ~ N 0, σ) is the Gaussian white noise, and x0 denotes the initial state.

Main objective of the present study is to investigate miR-26a and miR-101 levels, which both target EZH2, for their association with molecular pathways and with efficacy of tamoxifen as first-line monotherapy for metastatic breast cancer.

Our findings indicate that slightly elevated nonpolypoid colorectal lesions progress towards cancer along a relatively distinct route, exploiting certain specific molecular pathways along with others shared with their polypoid counterparts (although the dysregulation at this level is less severe).

Gene expression alterations at the 72-hpf time point were highly enriched with genes and molecular pathways associated with neurological development and disease.