The main goal of genetic studies is to unravel molecular pathways underlying primary headache disorders, in order to discover new therapeutic targets.
Although it is well established that immunosenescence has an important role in vaccination response, the molecular pathways underlying this process are largely unknown.
Human hair follicle mesenchymal stem cells (hHFMSCs) are an important source of cardiovascular tissue engineering for their differentiation potential into smooth muscle cells (SMCs), yet the molecular pathways underlying such fate determination is unclear.
However, the molecular pathways underlying alterations in energy metabolism and increased dependency on glycolysis have not been fully delineated.
A comprehensive understanding of molecular pathways underlying GBM behavior would enable the development of targeted therapeutic approaches.
Genetic analyses of zebrafish heart revealed many fundamentally important molecular pathways underlying its formation and function, which are conserved among all vertebrates including human [3] [5].
Molecular pathways underlying the activation of dendritic cells (DCs) in response to Herpes Simplex Virus type 1 (HSV-1) are poorly understood.
This study adds new information to our understanding of the molecular pathways underlying normal and abnormal cardiovascular development, paving the way for the development of novel prenatal screens and treatments for human fetuses with CHDs.
In our current study, we have investigated the molecular pathways underlying the growth suppressive functions of CHFR by utilizing genetic rescue experiments with colon cancer cell lines in which endogenous CHFR is epigenetically inactivated.
Molecular genetic analysis of preinvasive lesions, free from background noise associated with commonly studied advanced tumors, is essential to the identification of key genes and corresponding molecular pathways underlying early events in neoplastic transformation and cancer development.
As a large number of genes fall into this class of low abundance expression [10], this lack of sensitivity potentially compromises current efforts to gain a complete picture of molecular pathways underlying GBM.
