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To this end and by the use of bioinformatics, the molecular pathways, the defining markers, as well as the microenvironmental and genetic factors, which are implicated in the maintenance of stemness, chemo- and radioresistance in BCSCs, are identified and presented.
Despite its association with diverse substrates and molecular pathways, the functional role of this enzyme in disease, and normal biology is largely unknown.
Thus our transcriptomic analysis links two highly conserved molecular pathways the BMP signaling and the TPH1 5-HT axis on glucose homeosTPH1 5-HT
cGMP exerts its effects mainly via 3 molecular pathways, the PDEs, cyclic nucleotide-gated ion channels (CNG channels), and cGMP-dependent protein kinases (PKGs).
In the evolution of complex molecular pathways the additional USP genes generated by WGD or SSD events could have provided substrate material for neofunctionalization or subfunctionalization.
It enables the estimation of transcript abundance, the detection of altered genes and molecular pathways, the detection of fusion genes and the reliable identification of genomic variants [ 11- 15].
Similar(49)
The molecular pathways controlling the events involved in closure of the optic fissure are largely unknown.
The molecular pathways underlying the cell-type-specific response are currently investigated by us.
Identification of the molecular pathways driving the malignant phenotype remains elusive in PCC/PGL.
The molecular pathways and the role of autophagy in DMD had not yet been investigated.
The molecular pathways underlying the development of EMT are coming to light and may present novel avenues for therapeutic intervention.
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