Sentence examples for molecular pathways such from inspiring English sources

Furthermore, the development of treatment modalities aimed at targeting specific molecular pathways, such as Janus kinase (JAK) inhibitors, has resulted in a paradigm shift; several ground-breaking studies have proved their efficacy and they are now being licensed for first-line therapy in myelofibrosis.

This was anticipated since several disease processes and molecular pathways such as apoptosis, dyregulated calcium signalling, decompensated contractility, G-coupled protein receptor down-regulation, and maladaptive angiogenesis also connect cardiomyopathy of disparate etiologies [2].

We also identify components of key molecular pathways such as signal transduction and mating type.

AD has a complex pathology involving several molecular pathways, such as amyloid deposition, taupathy, oxidative damage, inflammation and metabolic changes.

In addition, evidence of land plant molecular pathways, such as the ethylene response pathway, in the charophytes would reveal the origins of key plant molecular processes.

Several mechanisms by which hypothermia exerts its protective effects have been characterized, including reduction in excitotoxin accumulation and inhibition of molecular pathways such as apoptosis and necrosis [ 4].

Human hair follicle mesenchymal stem cells (hHFMSCs) are an important source of cardiovascular tissue engineering for their differentiation potential into smooth muscle cells (SMCs), yet the molecular pathways underlying such fate determination is unclear.

To determine whether common molecular pathways mediate such shared HSC responses during differentiation, mobilization, and leukemic transformation, we next performed a meta-analysis of the differentially regulated genes from these three pairwise comparisons.

31 Tetracyclines can affect molecular signaling pathways, such as the inhibition of calcium/calmodulin pathway and inhibition of protein kinase C activity.

Although research has shown that PGRN exhibits anti-inflammatory properties, the details about the exact molecular pathway of such effects, and, in particular, the PGRN binding receptor, have not been identified so far.

However, the underlying molecular pathway elements, such as the decisive secondary regulatory factors of the major genes responsible for controlling prenatal muscle growth, remains poorly understood.