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Their interactants and involvement in molecular pathways relating to cancer is summarized in Additional file 1. Statistical testing for patterns in high throughput mRNA expression data has long been the primary method for defining biomarkers in human cancers.
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Furthermore, we showed that 25 genes and their related molecular pathways related to cell growth and antiapoptosis were strongly associated with radiation resistance in OSCC (Ishigami et al, 2007).
Advances in the understanding of the molecular pathways related to tumor growth and metastatic spread have resulted in the development of targeted therapies designed to act on specific genes or molecules of these pathways.
In this Review, we describe evidence of cellular and molecular pathways related to renal repair and regeneration, and review data from animal and human studies that show that the kidney might have regenerative capacity.
In the present paper we tested the enrichment of molecular pathways related to inflammatory cascades (IL-1, IL-2, IL-6, IL-8, TNF and INF) testing whether genes related to these systems hold more variations associated with the risk for BD than expected.
In order to elucidate the molecular pathways related to general intelligence, here we characterized the gene expression patterns in the PFC of mice with high general learning abilities relative to those of mice with low general learning abilities in an effort to identify functional clusters of genes that may underlie this cognitive trait.
Furthermore, several relevant GO terms and molecular pathways related to obesity, are presented here.
The identification of molecular pathways related to ALS remains an important challenge, nevertheless.
We recently identified genes and molecular pathways related to radioresistance of oral squamous cell carcinoma (OSCC) using Affymetrix GeneChip.
Basic research to identify the molecular pathways related to endocrine resistance and mammographic density is also needed.
In addition to direct approaches to hypoxia, targeting molecular pathways related to HIF-1 pathways is promising to improve the efficacy of radiation therapy.
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