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This is not unexpected, since both Uch37 and Rpn13 have been implicated in distinct molecular pathways presumably independent of their mutual interaction.
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Presumably, additional deregulations in downstream molecular pathways (breakdown of oxidative defense, eNOS uncoupling) occur with additional aggravation of conditions, diverting BK-induced signaling and allowing oxygen radical production to prevail.
Presumably, their loss is imperative for concomitant perturbations in multiple molecular pathways typical of neoplastic transformation.
Disruptions in these molecular pathways can cause disease.
Molecular pathways and targets in prostate cancer.
Molecular pathways: involving microenvironment damage responses in cancer therapy resistance.
Scientists may never halt the process entirely: ageing is an opaque and complex mingle of molecular pathways.
If the diseases are similar in some molecular pathways, perhaps the heart attack drugs should be tested against muscular dystrophy.
Fulda S. Molecular pathways: targeting inhibitor of apoptosis proteins in cancer--from molecular mechanism to therapeutic application.
Cox, T. R. & Erler, J. T. Molecular pathways: Connecting fibrosis and solid tumor metastasis.
Dawson, T. M. & Dawson, V. L. Molecular pathways of neurodegeneration in Parkinson's disease.
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