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In the last year, calorie-restricted diets have been shown in various animals to affect molecular pathways likely to be involved in the progression of Alzheimer's disease, diabetes, heart disease, Parkinson's disease and cancer.
Functional annotation of the human airway basal cell signature points to molecular pathways likely important for known and potentially novel aspects of basal cell biology.
We have annotated components of molecular pathways likely to contribute to virulence and reproduction.
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While recent genetic discoveries have led to significant insight into molecular pathways of likely importance in epilepsy pathogenesis [15], these discoveries have not contributed to an understanding of molecular mechanisms that result in seizure-induced cell death.
They also identify transcriptional changes during spawning that suggest molecular pathways that likely regulate spawning events.
Collectively, these data indicate that DVAP-mediated molecular pathways are likely to be important for our understanding of the disease pathogenesis in humans.
While these findings demonstrate an etiological heterogeneity for ASDs, many of the genes appear to interact at the level of molecular pathways, making it likely that mutations of one ASD-implicated gene may affect the function of others [50].
10.7554/eLife.05198.012 Figure 4. Recoding due to RNA editing affects complete molecular pathways and is likely to be more advantageous in sites with high editing levels.
This proteomic profiling of Rab18 −/− sciatic nerve confirmed that RAB18 plays a key role in the cytoskeletal dynamics of the nervous system and identified perturbations in several distinct molecular pathways that are likely to be responsible for maintaining cytoskeletal function.
Our inference that proteins affecting a diverse range of molecular pathways are also more likely to experience adaptive evolution is consistent with this hypothesis.
A disease outcome likely results from aberrant activity of many different molecular pathways, and thus it is likely that epigenetic modifications occur at multiple genes or genic regions.
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