Sentence examples for molecular pathways known from inspiring English sources

Rather than reviewing detail molecular pathways known to disrupt organogenesis when perturbed, we highlight conceptual questions at the topobiological level and ask how cellular and molecular mechanisms can work to explain these phenomena.

Some of the molecular pathways known to be involved in mammalian fat store regulation are also important in flies [2], suggesting that Drosophila may represent a useful genetic model for mammalian obesity.

We then performed a differential gene expression analysis by Q-PCR, comparing the injured versus the paired uninjured explants by focusing on molecular pathways known to play a role in embryonic skeletogenesis and in the repair of other tissues.

Therefore, phases preceding mitosis utilize a variety of molecular pathways known as checkpoints to ensure that necessary steps for a phase have been completed and no severe DNA damage has gone unrepaired.

These models are based on the molecular pathways known to regulate longevity, reactive oxygen species (ROS) production, mitochondrial function, telomere protection, cell cycle control and senescence, protein homeostasis, and systemic inflammation [ 10].

We have also extended our work to show the different roles that Hsp72 and Hsc70 play in myeloma cells, and their involvement in the various molecular pathways known to be important to myeloma survival.

Indeed, when we explored genes and pathways that are differentially expressed in OVCAs that demonstrated complete responses to primary therapy but that harboured high vs low CREB pathway scores, we identified a series of molecular signalling pathways known to influence tumour behaviour, cellular proliferation and apoptosis (e.g., AKT, G-protein signalling, MAP/ERK, BAD).

These findings showed that miRNA/miRNA* interfere with molecular functions and pathways known to be deregulated at the transcriptomic level, as reported in the cited gene expression study (some additional information is given in Additional file 7).

Although various molecular pathways are known to participate in this cross-talk, a comprehensive understanding of the implantation process is still missing.

This analysis revealed several genes and molecular pathways already known to be involved in aging, thereby validating the screen.

Many of the underlying molecular pathways are known and each year we learn more about the respective key molecules.