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Since biological distinctions between subtypes of breast cancers likely reflect differences in the pathways of tumor development and disease prognosis, future studies should investigate the molecular pathways interconnecting MC genesis with breast tumorigenesis.
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Molecular pathways are interconnected, and thus, combination therapy is emerging as an appropriate strategy to treat certain types of cancer.
This study seeks to identify signalling pathways interconnecting late INa and SR-Ca2+-leak in atrial cardiomyocytes (CMs).
A complex network of signalling pathways interconnects the DDR with downstream phenotypic changes in senescence.
Identification of other downstream pathways interconnected with ALK has led to studies examining disruption of ALK-associated pathways.
Molecular pathways controlling lipid metabolism are highly interconnected.
This issue is even more complex as the molecular pathways regulating autophagy and apoptosis are interconnected.
Molecular pathways controlling lipid metabolism are highly interconnected and are not fully understood.
For example, we found Egfr to be interconnected in various dysregulated molecular pathways represented by different functional clusters including the calcium signaling pathway, neuroactive ligand-receptor interaction and the MAPK signaling pathway, as well as pathways in cancers such as pancreatic and colorectal cancers, which involve focal adhesion and regulation of actin cytoskeleton.
Although many molecular pathways are involved in the apoptosis-regulatory mechanism, evidences suggest that the cell cycle and apoptosis may be interconnected [22] [28].
Although a number of different molecular pathways have been shown to contribute to QC cell quiescence, it remains to be deciphered how they are interconnected to control self-renewal of the QC.
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