A number of drugs have been designed to target different molecular pathways, including paclitaxel and temozolomide [20].
The plastic component bisphenol A (BPA) is suspected to exert deleterious effects towards human health and targets various cellular and molecular pathways, including activity of ATP-binding cassette drug transporters.
Lrp4 is a multi-functional receptor implicated in the regulation of several molecular pathways, including Wnt and Bmp signaling.
Altogether, these data provide evidence that red wine polyphenols and delphinidin in particular, through direct interaction with ERα, activate molecular pathways including Src, ERK1/2, eNOS, leading to endothelial NO production, accounting for vasorelaxation.
The search for mechanisms of action has mostly focused on the involvement of molecular pathways, including the activation of specific serotonin receptors [9], [10], [11], the cAMP-CREB signaling pathway [12], and neurotrophins, particularly brain-derived neurotrophic factor (BDNF), fibroblast growth factor (FGF-2) and vascular endothelial growth factor (VEGF) [13].
Disruption of certain molecular pathways, including the Notch pathway (Phng et al., 2009), will cause excessive vessel regression.
Stress-activated molecular pathways include multiple inter-linked regulatory networks such as protein kinase signaling cascades that can efficiently transduce input signals into suitable outputs [ 1].
The activated ALK fusion proteins result in aberrant ALK signaling and oncogenic transformation through several molecular signaling pathways, including PI3K/AKT/mTOR, JAK/STAT, and RAS/MEK/ERK [ 10].
Various molecular signaling pathways including Wnt/ β-catenin are identified to be involved in maintaining CSCs and thus are responsible for the recurrence and poor prognosis of tumor.
The internal network structure of the NSAID-miR model covers molecular signaling pathways (including transcription and translation, protein-protein interaction, and protein modification) and miRNA regulation.
The detected species were predicted to regulate disease stage specific molecular functions and pathways, including apoptosis and response to DNA damage.
