A number of drugs have been designed to target different molecular pathways, including paclitaxel and temozolomide [20].
The plastic component bisphenol A (BPA) is suspected to exert deleterious effects towards human health and targets various cellular and molecular pathways, including activity of ATP-binding cassette drug transporters.
Lrp4 is a multi-functional receptor implicated in the regulation of several molecular pathways, including Wnt and Bmp signaling.
Altogether, these data provide evidence that red wine polyphenols and delphinidin in particular, through direct interaction with ERα, activate molecular pathways including Src, ERK1/2, eNOS, leading to endothelial NO production, accounting for vasorelaxation.
The search for mechanisms of action has mostly focused on the involvement of molecular pathways, including the activation of specific serotonin receptors [9], [10], [11], the cAMP-CREB signaling pathway [12], and neurotrophins, particularly brain-derived neurotrophic factor (BDNF), fibroblast growth factor (FGF-2) and vascular endothelial growth factor (VEGF) [13].
Disruption of certain molecular pathways, including the Notch pathway (Phng et al., 2009), will cause excessive vessel regression.
Activated Akt plays an important role in the regulation of several important molecular pathways, including cell survival, proliferation, and apoptosis.
At the cellular level, inflammatory cytokines such as IL-1β are regulated by multiple molecular pathways including the mitogen-activated protein kinase (MAPK) pathway.
The authors discovered that some key molecular pathways, including the ERK1/2 and Wnt pathways, certain oxidative-stress-related genes and p53 are dysregulated in HD iPSCs.
Several contigs of M. violaceum were similar to enzymes of these molecular pathways, including G proteins, protein kinases and Ras proteins.
