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Our gene expression analysis identified several immune, repair, and metabolic molecular pathways expressed in coral regions affected with white syndromes.
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Some molecular pathways were differentially expressed between early and mature biofilm (i.e. Ribosome; Purine Metabolism; and Glycolysis).
Studying those genes and the molecular pathways they affect when expressed is revealing potential therapeutic targets for mitigating toxic stress, he said.
Therefore, in this study, we conducted a global gene expression survey in 17 cortical and subcortical brain areas of male suicides with and without major depression versus matched psychiatrically normal controls aiming at the identification of molecular pathways that are differentially expressed, consistently, across those brain regions.
Gene set enrichment analysis (GSEA) and DAVID functional enrichment analysis were used to investigate the molecular pathways, enriched in differentially expressed gene lists between groups of tumors [ 24- 26].
The analysis of gene networks and the molecular pathways triggered by the CCs differentially expressed genes was performed using the QIAGEN's Ingenuity Pathway Analysis software (IPA) [ 58].
To identify potential key molecular pathways of the carcinogenesis of HGSC, differentially expressed miRNAs and mRNAs identified previously [ 29] were linked.
Ingenuity® Pathway Analysis software (IPA; http://www.ingenuity.com) was used to examine functional and molecular pathway enrichment for differentially expressed genes based on Fisher's exact test.
DIANA-miRPath v2.0 pathway enrichment analysis (Papadopoulos et al, 2009) was used to detect molecular pathways that are targeted by the miRNAs differentially expressed between fMBC and fFBC.
The DIANA-mirPath web-based computational tool [ 13] was used to identify molecular pathways potentially altered by the intersection of miRNAs differentially expressed in fractured bone.
To identify molecular pathways influenced by exposure to air pollutants, the differentially expressed genes were integrated with their protein products and queried for known interactions.
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