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These results suggest that SD-dependent synaptic modifications that involve NLGN1 are downstream of molecular pathways driving the transcriptional response to sleep loss.
To develop targeted therapy, we must know the molecular pathways driving tumor growth.
It is of interest to study the molecular pathways driving spontaneous regression in NB to unravel the molecular basis of NB development, to look for new potential differentiation markers and to determine the differentiation therapies that can be used to treat patients.
Identification of the molecular pathways driving the malignant phenotype remains elusive in PCC/PGL.
While numerous studies have examined genes underlying neoblast pluripotency, molecular pathways driving postmitotic fates remain poorly defined.
It is clear that the identification of alternative molecular pathways driving resistant growth would have important therapeutic implications.
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The understanding of the molecular pathway driving the development of at least some canine cutaneous MCT, its addiction to a dominant oncogene, coupled with the identification of a "druggable" target has resulted in significant progress toward its treatment.
In the spondyloarthropathies, the underlying molecular and cellular pathways driving disease are poorly understood.
No single study has yet specifically determined COX-2 expression in pure DCIS compared to invasive cancer and normal breast epithelium (from breast reduction tissue) and the relationship to surrogate molecular markers of pathways driving cell proliferation in DCIS.
Moreover, these data also highlighted new molecular candidates and signaling pathways driving brown thermogenesis and tissue remodeling.
High-power genomic sequencing approaches are needed to elucidate the genetic basis for inherited susceptibility to NPC and to identify the genes and pathways driving its molecular pathogenesis.
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