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And while context is allowed to play a more prominent role and more factors are assessed simultaneously in systems approaches, they are typically only internal factors (cell-internal and body-internal), and typically targeted through interventions in specific molecular pathways (corresponding to aspects 1 and 3 above).
Putative biological functions and molecular pathways corresponding to those identified genes were retrieved by bioinformatics analysis, through which a possible pathological role of bmMSC in the development of skeletal diseases in aging was proposed.
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Molecular genetic analysis of preinvasive lesions, free from background noise associated with commonly studied advanced tumors, is essential to the identification of key genes and corresponding molecular pathways underlying early events in neoplastic transformation and cancer development.
It is also worthy noticing that these conclusions confirmed the observation that the combination of heat and drought exceedingly complicates the corresponding molecular pathways compared to separate stress, rather than a simply additive effect.
The abundance of mRNAs and their fine-tuning by corresponding miRNAs in molecular pathways related to mitochondrial metabolic balance and oxidative stress, cell proliferation and differentiation, as well as muscle structural protein composition play an important role in these myopathies and meat maturation.
Utilizing genomic-scale gene expression and various types of molecular interaction data, several groups have started to address the challenge of identifying the molecular pathways that underlie the translation of different genotypic perturbations into corresponding phenotypic output, for example, a particular disease.
Disruptions in these molecular pathways can cause disease.
Scientists may never halt the process entirely: ageing is an opaque and complex mingle of molecular pathways.
If the diseases are similar in some molecular pathways, perhaps the heart attack drugs should be tested against muscular dystrophy.
Although the molecular pathways are not well understood, retinol causes new collagen to form in chronologically aged skin and in skin damaged by ultraviolet light.
Disease mechanisms that relates to molecular pathways.
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CEO of Professional Science Editing for Scientists @ prosciediting.com