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This article serves to review the (1) current molecular pathways comprising the cell cycle checkpoint machinery, (2) inhibition of Chk1 as an effective means of abrogating G2 arrest, and (3) current Chk1 inhibitors in use in phase I clinical trials.
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Little is known about the molecular details of PRR, but genetic studies have revealed an intricate system of several independent pathways, comprising error-free and error-prone sub-pathways that allow the bypass of replication-blocking lesions [54].
This required reconstruction of long biosynthetic pathways, comprising up to eight heterologous genes from plants.
The cumulative evidence shows several parallel biological pathways comprising the net nitrification process.
Positively induced pathways comprised those linked to cellular assembly and organization and cellular response to therapeutics, while functional pathways that were subject to down-regulation in topotecan-treated OC spheroids were associated with cell-to-cell signaling and interaction, metabolism, immune response, protein trafficking and molecular transport.
Full definition of a protein's function requires a combination of two features or 'dimensions': (i) a molecular function (e.g. an enzymatic activity) and (ii) a functional context (e.g. a pathway) comprising other proteins involved in the same process.
If the diseases are similar in some molecular pathways, perhaps the heart attack drugs should be tested against muscular dystrophy.
Disruptions in these molecular pathways can cause disease.
Scientists may never halt the process entirely: ageing is an opaque and complex mingle of molecular pathways.
Although the molecular pathways are not well understood, retinol causes new collagen to form in chronologically aged skin and in skin damaged by ultraviolet light.
Disease mechanisms that relates to molecular pathways.
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