Expression microarrays are a powerful tool that could provide new information about the molecular pathways regulating common lung diseases.
Although this might take years, such a strategy may ultimately identify molecular pathways for common human diseases, some of which might overlap, that are potential pharmacological targets.
More precisely, we constructed gene networks using physical and genetic interactions, transcriptional co-expression/regulation and localization, protein domain and gene chemical interactions, co-occurrence of disease-gene pairs in scientific texts, homologues implicated in generating similar phenotypes in other organisms, common molecular pathways between gene products, and common GO annotations.
A series of molecular pathways have in common a significant role in the pathogenesis and progression of atherosclerosis and cancer.
Identification of these conserved sequences will help elucidate important molecular mechanisms or pathways common to many species.
Moreover, comparison of gene expression patterns and gene functions at key points during development reveals several molecular pathways that are common to bilaterian embryos.
As researchers continue to develop interaction networks based on a common phenotype and medical records are increasingly made electronic, the power of comorbidity analysis to identify common molecular pathways in the pathogenesis of many diseases will increase too.
Radin's company looks for common molecular pathways that might account for drug pairs with apparent synergistic effects, searching for drug-protein interactions in the company's database.
The impetus for development of cancer therapeutics from non-cancer drugs stems from the fact that different diseases share common molecular pathways and targets in the cell.
Acute myeloid leukemia (AML) remains highly fatal, highlighting the need for improved understanding of signal pathways that can lead to the development of new therapeutic regimens targeting common molecular pathways shared across different AML subtypes.
