Sentence examples for molecular pathways at from inspiring English sources
To reconcile the gap between the reported models and molecular pathways at the cellular level, we have related the single-cell-level in-vitro nanotherapeutics incorporation and its apoptotic action as well as drug efficacy in in-vivo tumor model.
Super-resolution imaging and proteomic profiling revealed distinctive distribution of active zone proteins and differential expression of core synaptic proteins and molecular pathways at the human NMJ.
The MetaCore software (GeneGo Inc, St Joseph, MI) was used to identify common molecular pathways at both doses and to create regulatory networks for selected pathways.
This conserved mechanism of gene silencing has led to exceptional use of reverse genetics methods and has led to a better understanding of molecular pathways at mechanistic levels [ 3].
GSEA provides a general statistical method to test for the enrichment of sets of genes in expression data, and has been particularly useful in identifying molecular pathways at play in complex gene expression signatures, as recently reported (Subramanian et al., 2005).
In the last decades, optical reporter genes for both fluorescence (FLI) or bioluminescence imaging (BLI) have been extensively employed to image molecular pathways at the transcriptional level or integrated into the genome for long-term expression and for the development of transgenic animals [ 3– 5].
These processes are mediated by many molecular pathways and, at least partially, via proteome-environment interactions.
There is increasing evidence that similar molecular pathways are at work in promoting age-related and obesity-related muscle dysfunction.
Therefore, present data suggest that it is very unlikely that the molecular pathways induced at 24 hours play a role in the survival of cells after one hour of treatment.
Although at the present time it is unclear whether the altered gene expression resulted in permanent alterations, the gene targets and molecular pathways identified at 72 hpf support a molecular basis for alterations of neurite growth and synapse formation and function that have been observed in previous studies.
Animal models of human cancers provide unique insights into the study and understanding of molecular pathways involved at both early and late stages of malignant diseases, easing the discovery of biomarkers and specific targets for new or more effective drug therapies (Etchin et al., 2011; Herreros-Villanueva et al., 2012a; Herreros-Villanueva et al., 2012b; Stoletov and Klemke, 2008).
