As mentioned, selection of tumour models should be based on both molecular characteristics, for example, expression or mutation of a target of interest or other relevant molecular pathology, either endogenously or through transfection/transgenic technology, together with desired properties such as the rate and reproducibility of growth, metastatic potential and chemosensitivity.
H&E-stained sections were scanned using the Aperio CS digital slide scanner (Queen's Laboratory for Molecular Pathology) and analyzed with ImageScope software (Aperio Technologies, Vista, CA, USA).
New technologies which enable dissection of the molecular pathology of PD are beginning to provide a more objective analysis of underlying sexual dimorphisms.
Recent insight on the molecular pathology of the disease as well as developments in imaging technology have furthered both the understanding on the autoimmune process in sympathetic ophthalmia and the targeting of prevention and treatment strategies for the future.
Although early attempts to use such technologies were of limited success, increased knowledge of the molecular pathology of tumors, of the immune system in general, and of tumor immunity in particular, has facilitated the production of more sophisticated anticancer vaccines.
This technology has contributed to our knowledge of the molecular pathology of breast tumours and shows promise as a tool to predict response to therapy and outcome, such as risk of metastasis.
"There is a need to develop better animal models, to recapitulate and predict effects of agents on the molecular pathology of the disease process, and also to develop better imaging and biomarker technologies to assess, as early and precisely as possible, drug effects in clinical studies," he says.
These targeted methods currently represent the vast majority of clinical sequencing for diagnostic medical decisions in molecular pathology, and they will likely be used for a long time as validation technology for any WGS approaches.
Our findings, although based on a limited number of AD-iPSCs, have highlighted the fact that molecular pathology of sporadic Alzheimer can be modelled in disease-related protein association networks by means of iPSC technology and transcriptome analysis.
Prof Geraldine Thomas holds a chair in molecular pathology at Imperial College London.
