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Based on these findings and its further implications, we believe that our quantitative computational model constitutes a valuable contribution towards the holistic mechanistic understanding of the molecular network supporting Golgi secretory function.
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We found that the set of highly reliable targets for approximately 20% of all human miRNAs constructed biologically meaningful molecular networks, supporting the view that the miRNA targetome generally constitutes the biological network of functionally-associated molecules in human cells.
The predicted targets derived from approximately 20% of all human miRNAs constructed biologically meaningful molecular networks, supporting the view that a set of miRNA targets regulated by a single miRNA generally constitute the biological network of functionally-associated molecules in human cells.
Accordingly, the current study provides insights into the molecular regulatory network supporting daily torpor in gray mouse lemurs stretching from the energy sensing AMPK pathway to specific downstream processes including gene transcription and mRNA translation.
The NMR results offer unprecedented insights into the changes in the molecular network and support existing deformation models.
This study sought to identify actionable gene targets in sarcomas by selective targeting of the molecular networks that support the growth of Ras-driven sarcomas in mice.
This study sought to identify actionable gene targets by selective targeting of the molecular networks that support sarcoma cell proliferation.
Understanding the molecular networks that support sarcoma cell proliferation may enable the development of therapies based on selective targeting of proliferation-relevant cellular pathways.
Thus far, the construction of a network comprising more than 100 nucleic acid molecular gates has been reported [27], suggesting that, the development of highly regulated molecular networks able to support complex decision-making criteria is feasible.
This has also spurred efforts to identify novel biomarkers to understand the impact of therapeutically altering the underlying molecular network on disease course, and to support decision-making in drug discovery and development.
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CEO of Professional Science Editing for Scientists @ prosciediting.com