Exact(18)
There are data addressing the molecular mutation rate.
The available data are all consistent with a GC-type molecular mutation pattern.
Comparison of phenotypic versus molecular mutation rates in these populations should provide phenotypic markers for assessing future TILLING populations.
Instead a distinct molecular mutation pattern exists, further differentiating mucosal melanomas biologically from their cutaneous and uveal counterparts.
The high rate of fitness-altering mutations suggests that the molecular mutation rate is higher in D. discoideum and/or a larger percentage of molecular mutations alters fitness.
Ghent-2 clearly encourages the exclusion of related syndromes through clinical evaluation, as well as through molecular mutation analysis, and hence it may improve the guidance of therapy.
Similar(42)
There are only few reported cytogenetic and molecular mutations in NLPHL, including common rearrangements of the BCL-6 gene [34] and that of SHM of SOCS1 loci.
Next-generation sequencing (NGS) platforms have evolved to provide an accurate and comprehensive means for the detection of molecular mutations in heterogeneous tumor specimens.
Functional assays are mainly designed with Anti-Thrombin or Anti-Factor Xa chromogenic methods and are useful for detecting genetic molecular mutations with decreased inhibitory activity and contributed to study the conformational changes of antithrombin and its variants, which potentially regulate the activity of this serine protease inhibitor.
There was also a lack of variation in the frequency of molecular mutations with only 2 sites having frequencies of the dhfr/dhps quintuple mutation above 4%, and all sites with a high frequency of the dhps double mutation also had a high frequency of the dhfr triple mutation.
Imaging features of glioblastomas may correlate with molecular mutations.
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