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Molecular monitoring of the intestinal bacterial communities by DGGE (Figure 4A) demonstrated that the acute stage of colitis was characterized by a shift towards members of the Enterobacteriaceae (Figure 4A).
However, limited access to serial tumor biopsies constitutes a major shortcoming in longitudinal molecular monitoring of targeted treatment.
Molecular monitoring of the presence of hybrid transcript in peripheral blood, previously positive, was converted to negative after GvHD development.
9 Molecular monitoring of the BCR-ABL transcripts by quantitative real-time polymerase chain reaction should be conducted every 3 months until a major molecular response is achieved and confirmed and at least every 6 months thereafter.
Among the most powerful tools for the control of trade in fisheries and wildlife are molecular monitoring of commercial outlets (e.g. markets and restaurants) and genetic tracking of products (Baker 2008).
32 Systems could be established whereby a positive POC test (on either urine or swab) triggers forwarding of the urine specimen or collection of an additional swab for molecular monitoring of markers of resistance.
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33 This analysis used the complete molecular monitoring dataset, consisting of 3627 blood samples from 476 patients in the imatinib arm of the IRIS trial.
The general approach of molecular monitoring provides a means for appraising therapies in the setting of subclinical disease.
Our objective was to examine the association between adherence to tyrosine kinase inhibitors (TKIs) and molecular monitoring and the risk of disease progression or mortality among patients with chronic phase chronic myeloid leukemia (CML).
Nowadays, highly sensitive and fast methods (for example, quantitative real-time PCR) facilitate molecular monitoring and early detection of relapse, thereby allowing direct treatment intervention.
Molecular monitoring has the highest sensitivity of current tests for treatment responses in CML; in clinical practice, it is typically used once patients have achieved complete cytogenetic response.
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