Much progress has been made during the past few decades in identifying the molecular events underlying modifications of DNA and chromatin.
The molecular changes underlying epigenetics modifications include DNA methylation and histone modifications.
High levels of RANTES, IL-1ra, MIP-1alpha, MIP-1beta, IL-2, IL-4, IL-5, IL-6, IL-7, IL-17, PDGF-BB, VEGF and IFN-gamma were found in plasma of atherosclerotic patients and might also be integrated in the molecular networks underlying atherosclerotic modifications of these vessels.
It will be worthwhile to study the molecular mechanisms underlying the morphological modifications, which would reveal molecular basis for the probable key innovations.
Thereafter, in order to gain insight on the molecular mechanisms underlying these anatomical, biochemical and physiological modifications elicited by EGb 761, we analyzed the global gene expression in the rat soleus muscle by DNA microarray analysis.
Recent structural and biochemical studies elucidated the complex molecular mechanism underlying CRL activation by the NEDD8 modification.
DOI: http://dx.doi.org/10.7554/eLife.04070.002 The molecular mechanisms underlying animal multicellularity evolved, in part, through the modification of ancient adhesion and signaling pathways found in the unicellular and colonial progenitors of animals.
A complete picture of the genes and molecular mechanisms underlying these traits is often lacking, which complicates targeted modification.
Based on the improved understanding of the molecular pathways underlying HNSCC, targeted drugs (e.g. EGFR-specific antibodies) and other modifications have been implemented in treatment protocols [ 16].
Genetic modifications at specific sites of animal genomes represent a powerful method for elucidating molecular mechanisms underlying normal and pathological processes.
