Hamon, M. A. et al. Histone modifications induced by a family of bacterial toxins.
to evaluate sleep modifications induced by chronic benzodiazepines (BDZs) abuse.
Leung, A., Trac, C., Du, J., Natarajan, R. & Schones, D. E. Persistent chromatin modifications induced by high fat diet.
Although this and other modifications induced by MGO cannot be excluded and are likely to account for the plethora of noxious effects of MGO in cells, our study provides robust data that elucidates an independent molecular mechanism whereby MGO can lead to proteasomal degradation of HIF-1α mediated by CHIP.
To more precisely elucidate the molecular modifications of 4E-BP1 induced by PP242 that induce eIF4E binding, whole cell lysates were prepared from HEK293 cells that were subjected to short (30 min) treatment with PP242 or rapamycin followed by 2DE (isoelectric focusing and SDS-PAGE) and western blot analyses.
All these chemical modifications induce differences in the mechanical properties of the self-grown mycelium materials.
CAFs can promote the tumorigenic conversion of epithelial cells, whereas fibroblasts derived from normal tissue suppress this transition [ 75], reinforcing the existence of molecular modification of fibroblasts induced by epithelial tumour cells.
We therefore propose a new model of NS1 functional regulation dependent upon several different molecular arrangements of the protein, which may be temporally, spatially, interaction, or modification induced.
The injury begins inducing molecular modifications that subsequently evolve into cellular damage.
Shroff, R. et al. Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break.
