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Previous studies have demonstrated that CHM treatment activates macrophages both in vivo and in vitro, inducing several molecular modifications in macrophages.
However, integrated molecular modifications in lipid saturation, kinetic properties of metabolic enzymes, contractile proteins, and transmembrane transporters are also essential for maintaining higher functions (Pörtner, 2002).
A key point for the interpretation of p53 and BAX results are the molecular modifications in response to chemoradiation (Rosen et al, 1999).
The molecular modifications in costamere turnover and energy homoeostasis identify that aspects of atrophy and fibre transformation are detectable at the protein level in weight-bearing muscles within 3 days of unloading.
The widely used size-based criteria have increasingly become inadequate where early measures of response are required to avoid toxicity of ineffective treatments, as biological, physiologic, and molecular modifications in tumours occur before changes in gross tumour size.
These neurons are heavily involved in the processes of neuropathic and inflammatory pain accompanied by molecular modifications in the interplay of extra- and intracellular milieus – the playground of PI3Kγ.
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Molecular modification in structures of biologically active substances that occur naturally is one of the main strategies to enhance healthy biological effects, as well as to reduce eventual side effects [1 3].
We investigated the transcriptomic response that underlies the induction of the metal-elicited molecular modification in C57/Bl6J mice.
MSG biopsy was employed in the study both to confirm the diagnosis of pSS and to evaluate histological and molecular modification in the tissues, following treatment.
SC1 sought to address whether changes in gene expression are sufficiently informative to infer the molecular modifications observed upstream, in particular, the phosphorylation status of effector proteins.
The understandings of the electronic structure and optical properties according to the molecular modifications are useful in the rational design of the zinc-porphyrin-based sensitizer in the solar cells.
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