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Therefore, in-depth understanding of their electronic-structure properties and rational molecular modifications are urgently required.
The understandings of the electronic structure and optical properties according to the molecular modifications are useful in the rational design of the zinc-porphyrin-based sensitizer in the solar cells.
With C214 as a prototype, molecular modifications are then made and a scheme, using NH groups to connect neighboring phenyls in the triphenylamine donor, has been demonstrated to be successful to significantly red-shift the absorption maximum wavelength, extend the lifetime of the first excited state, and decrease the energy gap between HOMO and LUMO.
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Through rational design several novel imidazoquinoline and oxoadenine TLR7/8 agonists, each with unique molecular modifications, were synthesized and assessed for their ability to augment adaptive immunity.
An increase in activity after molecular modifications was also observed in several of our piggyBac chimeras including the GAL4- piggyBac which displayed a fluctuated activity that was sometimes higher than the wild-type piggyBac transposase (15 and Meir et. al., unpublished observations).
Several steps, such as redox reaction sulfidation, phosphorylation and molecular modification, are involved in biotransformation [50].
Molecular modification is a quite promising strategy in the design and development of drug analogs with better bioavailability, higher intrinsic activity and less toxicity.
The analysis of mutant organisms generated by molecular modification is important in determining the functions of the wild-type genes.
Immunogens based on reduced amide pseudopeptides based on site-directed molecular modifications represent structural probes that could be considered as novel vaccine candidates, as we have previously demonstrated.
There is currently no data about NF-Y ubiquitination, but the molecular basis for modifications are present, both in NF-YB (K135, K140, K146, K149 in the α-C) and NF-YC (K124 and K127 also in α-C).
Although the H5 HA cleavage motif site of MDk/W452(H5N8) bears polybasic residues denoting a high-pathogenicity phenotype in chickens, molecular modifications that are known to promote infection of mammalian hosts are not present in this virus (Supplementary Table S2).
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