Nodes are connected by ∼1 480 000 edges representing experimentally observed cause effect relationships that relate to expression, transcription, activation, molecular modification and transport as well as binding events.
Despite the fact that a number of studies have addressed the changes in morphology, physiology and behavior of diapausing T. urticae, the knowledge about the molecular modifications underlying and associated with diapause in spider mites is very limited.
When plants perceive stress signals from their surroundings, a number of physiological, biochemical and molecular modifications occur (Krasensky and Jonak 2012).
A summary of p73-interacting proteins and p73 post-translational modifications are shown in Figures 2 and 3. A thorough characterization of molecular modifications of p73 and identification of similarities between the other family members will help to fill-in the missing pieces in the p53-p73 puzzle and lead to identification of better agents for targeted tumor therapy.
Through rational design several novel imidazoquinoline and oxoadenine TLR7/8 agonists, each with unique molecular modifications, were synthesized and assessed for their ability to augment adaptive immunity.
As the diabetic heart is more prone to adverse molecular modifications of proteins and lipids, impaired autophagy may be particularly harmful and thus a potential contributor to the development of diabetic cardiomyopathy (194).
Genetic and molecular modifications such as transformation, deregulation of apoptosis, proliferation, invasion angiogenesis, and metastasis are characteristics of cancer [ 4].
A reduction in gross tumour size is delayed and lags behind these early biological and molecular modifications, so that clinical response criteria defined by size alone can be misleading.
We move from a structural overview to the broad cellular and synaptic context of neuroligins, intermolecular interactions, and molecular modifications that occur within a synapse.
