Simple molecular modifications, especially those aimed at reducing hydrophobicity [56], can often reduce efflux [57, 58].
Therefore, in-depth understanding of their electronic-structure properties and rational molecular modifications are urgently required.
Genomes and transcriptomes of different species are sequenced, which generate high-input information for genomic studies and molecular modifications.
When plants perceive stress signals from their surroundings, a number of physiological, biochemical and molecular modifications occur (Krasensky and Jonak 2012).
We move from a structural overview to the broad cellular and synaptic context of neuroligins, intermolecular interactions, and molecular modifications that occur within a synapse.
In this Opinion, I propose an epigenetic clock model that outlines how molecular modifications, such as DNA methylation, are integral components for timing endogenous biological rhythms.
Immunogens based on reduced amide pseudopeptides based on site-directed molecular modifications represent structural probes that could be considered as novel vaccine candidates, as we have previously demonstrated.
In this context, the molecular modifications or synthesis of compounds continue being the best strategies for the identification of new compounds for the treatment of pain and inflammation.
Through rational design several novel imidazoquinoline and oxoadenine TLR7/8 agonists, each with unique molecular modifications, were synthesized and assessed for their ability to augment adaptive immunity.
After multiple rational molecular modifications, BSN3 could grow on xylose and convert xylose to ethanol, but its efficiency was not high, similar to previous reports (Demeke et al. 2013; Diao et al. 2013).
Further molecular modifications of the cis derivative led to the development of potent analogues which indicated successful bioisosteric replacement of the piperidine ring by a pyran moiety in these 3,6-disubstituted derivatives.
