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Tanaka, H. et al. Molecular modification of N-cadherin in response to synaptic activity.
This observation suggests that there is an advantage to the molecular modification of DARPin 23.2, an enhanced affinity for CD4.
The major targets of molecular modification of starch by enzymes include the amylose content, the molecular mass, and the structure of amylopectin chains.
This is the first report of a gene therapy vector engineered to discriminate between infection in malignant and normal cells by molecular modification of a tumor-specific protein.
The structure activity relationships of CSA analogues as safeners and fungicides were discussed and it might be valuable for further molecular modification of new CSA analogues.
Bioprecursors do not imply a temporary linkage between the active principle and a carrier group, but result from a molecular modification of the active principle itself.
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The molecular modifications of urocortin 3[36 38] led to an improved understanding of the relationship between molecular structure and biological activity of this peptide, and the novel peptidomimetics could be further tested for possible clinical treatment of depression.
Further molecular modifications of the cis derivative led to the development of potent analogues which indicated successful bioisosteric replacement of the piperidine ring by a pyran moiety in these 3,6-disubstituted derivatives.
The molecular modifications of the new improved vaccine also translated in the induction of significantly enhanced immune responses and complete protection at a dose 100 times lower than with the previous generation adenovirus-based Ebola vaccine.
Our findings define extensive genome-wide molecular modifications of histones in adipocytes that are directly associated with overweight and diabetes.
These epigenetic marks or modifications correspond to molecular modifications of the DNA, such as methylation of cytosines and modification of proteins associated with DNA such as histone methylation, acetylation and deacetylation, and phosphorylation, without affecting the DNA sequence per se.
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