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A possible molecular model underlying the role of ERK in the different temporal phases of synaptic plasticity consists in ERK being activated immediately after synaptic stimulation.
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This approach retrieves molecular processes integrating molecular features from more than one species, by this providing molecular process models underlying cooperative phenomena.
Using yeast as an experimental model, the molecular mechanisms underlying ubiquitination-mediated membrane trafficking were intensively investigated [3], [9], [10].
The multistep model for molecular aberrations underlying colorectal carcinogenesis is likely to apply equally for both tumor subsites [ 7, 8, 15].
Wild type (WT), calreticulin-deficient (CALR−/−), and calreticulin truncation variant (CALR−/−-NP and CALR−/−-PC) pluripotent stem cells were used to investigate molecular remodeling underlying a model of cardiopathology.
These genes provide a basis for developing hypothetical models of molecular mechanisms underlying SjS, as discussed below.
The methodology presented in this work combines semantic information retrieval and experimental data through context-specific modeling of molecular interactions underlying stages in Alzheimer's disease (AD).
In zebrafish embryos, nipblb loss of function resulted in alterations of the Wnt/beta-catenin pathway, modeling the molecular defects underlying NIPBL-mutated CdLS patients.
Although the response to anti-EGFR mAbs observed in some patients has confirmed that EGFR activation is oncogenic, as predicted by cellular and animal models, the molecular mechanisms underlying EGFR activation in colorectal cancer remain obscure and are probably heterogeneous.
The use of genetically engineered mice has greatly expanded the utility of the model in studying molecular mechanisms underlying the renal response to UUO.
These data provide significant insights into the molecular differences underlying the Flinders model, and have potential relevance to broader depression research.
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