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The molecular model, in which several ANs linked by bridge bonds or hydrogenated aromatic rings, is valid at least for the PA.
By this we study two models, one is the fully flexible molecular model in which n-alkane is subject to bending and torsion, while the other is the rigid molecular model in which all carbon atoms reside on the same plane.
We propose a molecular model in which slow inactivation (IS) occurs by a closure of the outer vestibule, whereas IUS arises from a constriction of the internal vestibule produced by a widening of the selectivity filter region.
The location of these residues are displayed on the eIF4E molecular model in Figure 5 (Panels A and B in magenta and pink, respectively).
In the present study, we provide evidence of a molecular model in support of this hypothesis.
These observations are consistent with our recently-published molecular model in which wild type functional p53 behaves as an important transcriptional repressor of PLK1.
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This study demonstrates the potential importance of molecular modeling in the design of new biomaterials.
Additionally, there have been published studies showing the advantages of 3D molecular models in the classroom [7].
Implementation of molecular modeling in the MIP sorbent development process appears to provide a solution to this problem.
We also refer to the new modeling strategies which integrate macroscopic and microscopic methods, and to the possibilities of molecular modeling in polymer nanotechnologies.
The application of 2D-NMR spectroscopy and Molecular Modeling in determining the active conformation of flexible molecules in 3D-QSAR was demonstrated in the present study.
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