Sentence examples for molecular mediators that from inspiring English sources

Receptors, transporters and enzymes are the key molecular mediators that regulate and maintain serotonin levels in the brain and periphery.

Hepatocellular injury usually leads to inflammation and activation of the innate immune system, leading to release of growth factors, cytokines and small molecular mediators that can stimulate extracellular matrix (ECM) synthesis by activation of quiescent hepatic stellate cells and fibroblasts/myofibroblasts (collectively named HSCs) [1], [2].

By understanding the molecular mediators that lead to tendinopathy, novel therapeutic targets could potentially be identified for drug development.

Deciphering the molecular mediators that underlie the cytoprotective effects of preconditioning can pave the way to important therapeutic possibilities.

However, further studies are needed in order to identify the molecular mediators that participate in the process of transdifferentiation.

COXs convert arachidonic acid into prostaglandin H2 which is then metabolized into various prostaglandins, prostacyclins, and thromboxanes, which are the molecular mediators that start the inflammatory process [ 2].

To identify a potential molecular mediator that may be involved in these effects, we investigated the secretion of a number of growth factors and cytokines that are pivotal to bone metastasis.

Chelated Mn3+ in turn act as low molecular weight mediators that are able to attack phenolic structures.

These changes result in a sequence of pathological events that includes impaired cell-cell communication between epithelial cells and fibroblasts, and development of fibrotic lesions that disrupt the normal tissue architecture and lead to impaired expression of the correct molecular cues and cellular mediators that maintain normal tissue structure and function.

It is therefore important to characterize the molecular events and mediators that drive this inflammatory response, and vice versa, to identify protective factors that could provide improved therapeutic options.

We therefore established an interactive model in vitro that determines RA-related molecular processes in chondrocytes induced by soluble mediators that were secreted from RASF.