Sentence examples for molecular link that from inspiring English sources
The coordinated downregulation of these miRNA clusters, and the analogous regulation of clonal expansion by miR-200c, provides a molecular link that connects BCSCs to normal stem cells [ 56].
The finding that these signaling pathways converge upon the integrative genes to potentiate the cellular response provides the molecular link that would permit the flow of the integrated information to be controlled by a regulator of either one of the stress signals.
In this study, Rui Yang et al. present an interesting finding that IL6 affects CD4 T cell effector functions, especially IL-21 and IL-4 production, via the regulation of mitochondrial calcium and membrane potential, a molecular link that has not been explored before.
Furthermore, we identified BH3-only protein p53 upregulated modulator of apoptosis (PUMA) as the key molecular link that orchestrates overwhelmed ER stress to mitochondria-mediated apoptosis, involving mitochondrial reactive oxygen species, in a p53-independent manner.
p62/SQSTM1 may therefore be a molecular link that not only has a role in the interplay between UPS and autophagy, but also co-regulates caspase-8 activation both during extrinsic caspase-8-dependent apoptosis and during intrinsic scenarios of apical caspase-8 activation.
This review describes nanoscale particulate and substrate parameters that influence both the uptake of nonviral gene carriers and the endocytic phenotype of interacting cells, and explores the molecular links that may mediate these interactions.
The molecular links that connect inflammation and liver tumors are not fully known; however, recent studies are beginning to unravel the underlying mechanisms.
Despite the understanding of downstream responses of phagocytosis of particulates, the exact molecular links that connect these events to NLRP3 activation remain to be elucidated [ 233].
The molecular links that connect cancer cells and TAMs are not completely known, but recent studies have demonstrated that NF- κB, STAT-3, and HIF-1 signaling pathways play key roles in this crosstalk.
Comparison of miRNA signatures derived for distinct mammary epithelial subsets from normal mammary tissue with those of different breast cancer subtypes further strengthened the molecular links that have been previously defined at the mRNA level.
In fact, the combination of both stress signals intensifies the output of the different pathways upon NRP expression; therefore, NRPs serve as molecular links that integrate the ER stress and osmotic stress responses.
