Vascular endothelial cells (ECs) have a finite lifespan when cultured in vitro and eventually enter an irreversible growth arrest state called "cellular senescence". It has been shown that sphingolipids may be involved in senescence; however, the molecular links involved are poorly understood.
73 A suggested molecular link between glycotoxins and cancer biology involves the activation of an inflammatory cycle of persistent oxidative stress that favors cancer development.
Previous reports identified a potential molecular link between KPNA2 and c-Myc, involving TGF- β1 and IFN- γ.
Itch induces ubiquitination and degradation of these transcription factors involved in TH2 differentiation, providing a molecular link between Itch deficiency and the itching phenotype [21].
Furthermore, we identified BH3-only protein p53 upregulated modulator of apoptosis (PUMA) as the key molecular link that orchestrates overwhelmed ER stress to mitochondria-mediated apoptosis, involving mitochondrial reactive oxygen species, in a p53-independent manner.
In fact, MAPK specifically the extracellular signal-regulated kinase (ERK) subfamily of MAPKs may be the molecular link between E-LTP and L-LTP, since many signaling cascades involved in E-LTP, including CaMKII and PKC, can converge on ERK.
We propose that A4GALT is involved in the progression of various ovarian and peritoneal cancers; however, the molecular link between A4GALT mRNA levels and P1 expression remains unknown.
The protein OS-9 was reported to be involved in both, the activity regulation of HIF and ER associated degradation, and thus promised to be a molecular link between these processes.
Ling, C. & Groop, L. Epigenetics: a molecular link between environmental factors and type 2 diabetes.
Sakurai T, Kudo M. Molecular link between liver fibrosis and hepatocellular carcinoma.
