To develop suitable MR imaging probes with improved sensitivity for noninvasive in vivo imaging at the cellular and molecular levels, we synthesised multifunctional PFC-based nanoemulsion containing ICG as a NIR organic dye, which provides simultaneous 19 F-based MR imaging and NIR optical imaging.
By following an approach from the intact animal to tissue, cellular, and molecular levels, we found that repair of chronic MI by cytokine treatment significantly reduced the occurrence of arrhythmias.
Bridging the tissue and molecular levels, we used TEM to characterize tissues, cells, organelles and specific proteins in situ (immunocytochemistry).
Since Alethea had clear effects on photosynthesis/chloroplastic function at the physiological and molecular levels, we also investigated the ability of Alethea to protect various crop species against methyl viologen, a potent generator of oxidative stress in chloroplasts.
At the molecular levels, we demonstrate that SL-LPS preferentially clears away the compensatory anti-inflammatory signals in monocytes/macrophages, in sharp contrast to the effect of low dose LPS (Deng et al., 2013, Maitra et al., 2012).
Using an integrative approach at the whole animal, isolated vessels, and molecular levels, we tested the hypothesis that the llama, a species that undergoes pregnancy under the influence of the chronic hypoxia of high altitude, delivers offspring with an increased α-adrenergic peripheral vascular reactivity compared with neonates from lowland species.
Yet despite the fact that we now have a much greater understanding of what the body is made of at a molecular level, we haven't seen the advances in medicine that had been hoped for.
At the molecular level, we found that LSD1 regulates osteogenesis-associated genes expression through its histone demethylase activity.
At a molecular level, we investigated the gene expression of key steroidogenic enzymes from the maternal ovary.
At the molecular level, we also revealed that the function of astrocyte-elevated gene-1 in promoting metastasis was associated with the activation of matrix metalloproteinase-9 expression.
Although ordinarily measured only on a molecular level, we have developed a new spectropolarimetric instrument, TreePol, that allows for both laboratory and in-the-field measurements.
