Our present results provide molecular level support for the models in which the LD initially grows inside the ER membrane leaflets as an oily aggregate [48], [49], [50].
Our disease network links it to a number of cancers (including squamous cell carcinoma and melanoma) in addition to some other benign skin conditions such as Nevus (Figure 1), which provides molecular level support for the clinical warning that Actinic keratoses are precancerous [27].
Diagnosis and treatment are facilitated by the huge amount of information coming from genomics and proteomics research, allowing molecular level support for medical decisions.
Furthermore, this study provides molecular level support for utilization of potential prebiotics, some of which are already known to be bifidogenic, and paves the way for expanding synbiotic formulations targeting specific groups of probiotic bacteria.
Our results show that the two disorders also share similarities at the molecular levels further supporting the assumption that irritable bowel syndrome may actually belong to early signs of gastrointestinal involvement in PD [ 32].
It is important to provide experimental proofs at the molecular level to support the theory for the effectiveness of orally administered cytokine drugs or proteins in clinical settings.
However, long-range restraints at the molecular level in support of this model are still missing.
Taken together, these results provide compelling evidence that G2.2 targets CSCs at a molecular level, which supports the phenotypic findings of spheroid growth inhibition described above.
The SEM and SFM images present direct evidence of an orientation of the slider on both a fibrillar and a molecular level and thus support the orientation mechanism postulated by Pooley and Tabor (Proc. R. Soc. London A, 1972, 329, 251).
The NF1 gene is thought to be a tumour suppressor gene, yet no direct proof at the molecular level exists to support this hypothesis.
