One example of the homing phenomenon at the molecular level involves a substance known as CXCL12 (chemokine stromal cell-derived factor-1), which is secreted by stromal cells (connective tissue cells found within organs).
Results of the genome analysis reveal that the potential role of CDX at molecular level involves the regulation of genes in signal transduction, ubiquitin-inflammation, mitochondrial-dysfunction, and damage-response pathways.
Our data indicate that rBPI21 mechanism of action at the molecular level involves the interaction with the LPS of the outer membrane of Gram-negative bacteria, followed by internalization and leakage induction through the (hemi fusion of the bacterial outer and inner membranes, both enriched in phosphatidylglycerol.
Structural studies on spinach aquaporin characterized the open and closed states and exhibited two different conformations of loop D revealing that the gating mechanism at molecular level involves a large movement of this loop [ 77].
Biological diversity is the product of organic evolution, and biological processes from the molecular level involving DNA to the biosphere are not intelligible without reference to organic evolution.
A significant number of studies on PK-based DDI have been done at the molecular level involving enzymes and transporters, and resulted in a large amount of experimental data [5].
There may be even closer links between these two disorders at the molecular level, involving the receptor activator of nuclear factor-κB ligand (RANKL).
Therefore, DRUGSURV indicates that clinical conditions modelled in the data set GSE3521 at the molecular level involve genes that are not modulated by sunitinib and, therefore, treatment with sunitinib is not expected to result in any benefit.
The second application deals with design at the molecular level and involves a considerably larger design space for identifying a replacement of Freon.
At the molecular level, this involves occupancy of discrete RPB-Jκ binding element(s) in the survivin promoter upon Notch activation, which results in transcriptional upregulation of survivin levels, inhibition of apoptosis, and acceleration of mitotic transitions selectively in ER-negative breast cancer cells [ 35].
