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Thus, we anticipated that smooth-muscle cells and fibroblasts in the aged prostate might exhibit alterations at the molecular level, reflecting age-related structural modifications, a response to the infiltration of inflammatory cells, or stemming from other intrinsic aging-related alterations.
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At the molecular level, abnormalities reflect a required role for SHP-2 in the activation of ERK and AKT kinases in bone-forming cells.
When the immune system is stimulated or tissue damage occurs, these cells go through multiple stages of activation, which at the molecular level are reflected by the activation of a cascade of innate immune genes (Graeber 2010).
iPSC generation has been suggested to be a stochastic process [ 9], which at a molecular level may reflect the stochastic nature of binding by the reprogramming factors to their target sequences due to transient exposure of these sites in the repressive chromatin environment [ 10].
Adaptive divergence at the molecular level may be reflected by an increased rate of non-synonymous changes within genes involved in adaptation [ 7].
Interestingly, it appears that differences in the state of a cell are not only detectable on a molecular level, but are also reflected in the morphology and the spatial arrangement of single mESCs and the resulting cell colonies.
The floral transition in azalea involves a series of changes at the molecular level that seem to be reflected in the levels of 5-mdC.
Moreover, the clinical overlap between the different IDs is reflected on molecular level by the identification of similar multilocus methylation defects in different phenotypes.
According to Thomas Carew, a neuroscientist at Yale University, the commonplace experience that the most reliable way to build a long-term memory is through repeated exposure to the thing to be remembered, rather than by short-term "cramming", is reflected at the molecular level.
The impairment of Jmjd3-kd cells in neural commitment is reflected at the molecular level in the impaired up-regulation of key inducers and markers of neurogenesis, like Pax6, Sox1 and Nestin.
How are these adaptive process reflected at the molecular level?
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com