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Despite the acceptance of the technique by cognate disciplines and the demonstration of its usefulness in a number of enabling technologies, relatively little is known about the molecular level events underlying the imprinting process and subsequent recognition events.
All gene expression molecular level events can be represented with reactions.
Alternatively, all-atom molecular dynamics (MD) simulations can provide details of molecular level events at high precision.
Thus, the observed patterns in conformational flexibility and their resultant effects on substrate pharmacological profile can be interpreted in understanding the molecular level events that influence biological reactivity.
A goal in systems biology research is to understand linkages from molecular level events to system phenotype: link genotype to phenotype.
For example, it was demonstrated in [ 57] that events involving anatomical entities are more reliably extracted than molecular level events, with performance levels for the former types of events reaching 80.91% precision, 72.05% recall and 76.22% F-score, despite the fact that the annotation corpus contained a larger number of molecular level events.
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Interestingly, we find that events involving anatomical entities are more reliably extracted than those involving molecular-level ones, despite the model incorporating information from a corpus with a larger number of molecular level event annotations than the total number of annotations in the MLEE corpus.
Understanding and predicting the physical interactions of small molecules with DNA via docking is key not only for the comprehension of molecular-level events that lead to carcinogenesis and other diseases, but also for the rational design of drugs that target DNA.
What molecular-level events determine the behavioral outcome of individual leukocytes during rolling, activation, and adhesion to venular surfaces?
The event counts show a higher density of anatomical than molecular-level events, although general biological events dominate overall.
We describe the results of the numerical analysis as apparent rates for the appearance of soluble products, and in doing so acknowledge the complexity of the molecular-level events contributing to each of the steps given in the kinetic schemes of Fig. 7.
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