Exact(3)
More recent developments of Reverse Genetics and Cell-Free Assembly systems have allowed integration of the accumulated structural and molecular knowledge to be tested at meticulous level, yielding higher insight into basic molecular virology, from which the rational design of safe efficacious vaccines has been possible.
Researchers and clinicians are attempting to further characterise neurological manifestations associated with mutations in ATP1A3, and to build on the existing molecular knowledge to understand how specific mutations can lead to different diseases.
Today, having adapted his lab to study biomarkers for cancer risk, Jorgensen does genetic epidemiology almost exclusively, mostly in collaboration with scientists who study DNA repair genes but have too little molecular knowledge to interpret the associations with disease.
Similar(57)
As these advances in molecular knowledge contribute to the biologic understanding of DLBCL, targeted treatment strategies can be developed and refined.
This is mainly due to the lack of detailed molecular knowledge and also to our aim, which is basically to attract the attention of the reader to a possible buffering effect at the protein level.
For example, nanoparticles are increasingly used in a number of applications, but as Nguyen T K Thanh (University College London) discussed, reliable methods to routinely produce high-quality nanoparticles are scarce and molecular knowledge is required to predict their formation and to tune their size and morphology.
Further molecular knowledge is required to understand how signals are relayed from the initial bacterium/epithelium point-of-contact, to other cells in the organ and onwards, to other tissues in the host.
In one case (GIST), understanding of the molecular etiology of the disease led to rational drug development; in another case (NSCLC), clinical drug development led to rational dissection of the underlying biology; and in a third case (RCC), an existing body of molecular knowledge provided a framework to begin to understand why a certain class of drugs may be effective.
The successful transfer of more complex molecular knowledge from A. thaliana to crops requires us to account for between-species differences in natural history.
A challenge presently facing plant scientists is to obtain the molecular knowledge and experimental tools required to identify the network of genes that condition crop adaptation to harsh environments.
It is hoped that "system characterization" by imaging probes will ultimately allow molecular knowledge developed in the laboratory to be translated to clinical disease management [ 50].
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