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In the post-genomic era, our molecular knowledge and modeling capabilities have allowed to start using such methodologies with success.
This is mainly due to the lack of detailed molecular knowledge and also to our aim, which is basically to attract the attention of the reader to a possible buffering effect at the protein level.
Another method of higher level analysis is to take advantage of the decades of molecular knowledge and organize transcriptional data into sets of genes that together perform a cellular process (Subramanian et al., 2005).
A challenge presently facing plant scientists is to obtain the molecular knowledge and experimental tools required to identify the network of genes that condition crop adaptation to harsh environments.
This work provides a foundation of molecular knowledge and tools that can be used to delve further into understanding the biology of G. holbrooki and how this organism can be used as a bioindicator organism for endocrine disrupting pollutants in the environment.
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Bis translates mechanistic cellular and molecular knowledge regarding the innate and adaptive immune response and reproduces the immune system's complex behavioral patterns.
We introduce a systems biology approach to study cancer that formally integrates the available genetic, transcriptomic, epigenetic and molecular knowledge on cancer biology and, as a proof of concept, we apply it to colorectal cancer.
Molecular knowledge of response and tolerance mechanisms will pave the way for engineered plants that can tolerate salt stress and could be the basis for production of crops which can result in economic yield under salt-stress conditions.
For example, nanoparticles are increasingly used in a number of applications, but as Nguyen T K Thanh (University College London) discussed, reliable methods to routinely produce high-quality nanoparticles are scarce and molecular knowledge is required to predict their formation and to tune their size and morphology.
Since 1988, molecular knowledge has increased considerably and structures and functions have been determined for most of them.
Today, microbial rhodopsin research is a flourishing research field in which new understandings of rhodopsin diversity, function and evolution are contributing to broader microbiological and molecular knowledge.
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