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Conversely, the molecular interplay between chromatin effector proteins and modified chromatin regions as well as their resulting biological output is less well understood on a molecular level.
Together this study is the first example of using population and single cell based transcriptome analyses to unveil the molecular interplay between different NSC/NPCs and their microenvironment in the context of the aging brain.
Analyzing the molecular interplay between malignancies and therapeutic agents is rarely a straightforward process, but we hope that this special issue of Seminars has highlighted the clinical value of such endeavors as well as the relevant theoretical and practical considerations.
They suggest that the molecular interplay between two translational repressors directly impacts brain functionality.
We are just beginning to understand the complex molecular interplay between the pathogen and the host which leads to disease.
However, the exact molecular interplay between the kallikrein/kinin-system and VASP in the context of hypoxia, inflammation and vascular leakage needs to be further established.
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Albeit several aspects remain to be defined regarding the conformation and function of native apoB-100, particularly regarding molecular interplays between particle lipids and the apoB-100, this study shows the potential of cryo-EM in resolving at least some of the concealed structural details of native LDL particles also at the physiological body temperature.
It is believed that multiple connections exist between autophagy and apoptosis, and so the molecular interplay and functional relationship between their pathways have gained considerable interest.
In the course of a bacterial infection, complex molecular interplays occur between host cells and bacteria.
This transporter-mediated molecular interplay represents a direct link between inhibitory and excitatory neurotransmission and functions as an adjustable negative feedback that may combat intense excitation in epilepsy.
More recently, the field of interest for autophagic cell death has widened due to the finding that autophagy deregulation is implicated in cancer, and because molecular interplays have substantiated a crosstalk between apoptosis and autophagy [20].
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