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Another approach is to introduce molecular interfaces between a solid surface and enzymes.
Secreted proteins are key molecular interfaces between parasite and host and enable H. glycines to infect soybean plants, which results in an estimated annual damage of $800 million to soybean production in the USA alone [ 5].
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As TLR represent a major molecular interface between hosts and microbial flora, this finding may help explain an isolated report of diminished islet mass in gnotobiotic rats [45].
We explored the molecular interface between CD81 and claudin-1 using a combination of bioinformatic sequence-based modelling, site-directed mutagenesis and Fluorescent Resonance Energy Transfer FRETT) imaging methodologies.
We investigated the molecular interface between CD81 and claudin-1 using a combination of bioinformatic sequence-based modelling, site-directed mutagenesis and Fluorescent Resonance Energy Transfer FRETT).
Crystal structures of KLHL3 Cul3NTD (where KLHL is Kelch-like protein) [ 63] and KLHL11 Cul3NTD [ 64] have revealed the details of the molecular interface between the BTB proteins and the Cul3 scaffold.
Gene expression studies have previously been used to address the molecular interactions and mechanisms that underlie the broadest range of biological processes that include drought resistance [ 14] and tolerance [ 15- 17] in addition to the characterization of the molecular interface between other candidate mutualisms [ 18] and controlled parasitisms.
The primary condition for reaching this high therapeutic efficacy is the perfect match between two molecular interfaces: (I) complementarity determining region of the anti-HER-2 antibody and the antibody docking domain of the HER-2 receptor; (II) the complementarity determining region of anti-HBsAg antibody and the antibody hosting domain of the HBsAg.
We show how such a coarse grained model may be used to guide the developer of filled elastomer applications in the understanding of the interplay between molecular interface design and macroscopic performance with respect to the Payne effect.
Epistasis between sites across a molecular interface could play a key role in determining the functions and evolutionary potential of molecular complexes.
The molecular binding interface between the fusion protein and the APN receptor is well packed, analogously to that of the Cry1Ac APN complex.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com