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In this review, I discuss novel findings elucidating the multiple molecular interdependence among cancer-specific signaling, cell metabolism, and epigenetics to provide an insightful understanding of how major cancer machineries interact with each other during cancer development and progression, and how this knowledge may be used for future co-targeting strategies.
Cross-talk between apoptotic and autophagic pathways has been reported, but their molecular interdependence is not yet clear (Ferraro & Cecconi 2007).
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In this study, the interdependence between molecular architecture and photo-polymerization is evaluated for self-assembled monolayers containing diacetylenes.
However, the molecular principles underlying this interdependence are not fully understood.
To explore the interdependence of molecular signaling events initiated by endothelial cells on tumor cells, we exposed HeLa to HDMEC CM in the presence of chemical inhibitors of STAT3, Akt, or ERK pathways and analyzed the interdependency of the phosphorylation events.
Mutual interdependence between this molecular parasite (intein) and its host protein (exteins) is not beneficial for intein spread but could be advantageous for intein survival during evolution.
Hub proteins in this network were considered to be the key nodes that regulate molecular mechanisms of CVDs and interdependence between CVDs and other complex disorders.
Interestingly, we observed a synergistic impact of combined Sirt1- and EGFR-inhibition suggesting a functional interdependence in PDACs, whose molecular details remain to be explored.
Our bioengineered skin-based system represents a robust platform to reliably assess the molecular and cellular mechanisms underlying the complex interdependence between epidermal cells and the immune system.
Numerous studies reveal a strong interdependence of MMP expression and activity with the molecular mechanisms that control the composition and turnover of periprosthetic matrices.
A large body of studies reveals a strong interdependence of MMP expression and activity with the molecular mechanisms that control the composition and turnover of periprosthetic ECMs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com