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Structural uncertainty was addressed by considering only molecular interactions supported by experimental evidence.
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This is achieved in aqueous systems by weak interactions supported by appropriate molecular and supramolecular architectures.
Knowledge of the LAMPs' globular domains and their sites of possible molecular interaction will support continued research on the role of these proteins in the cell.
New estimates of genotype × environment interactions support use of recently available molecular and genomics tools to identify the genetic basis of heat-stress sensitivity and tolerance.
These observations detailing the molecular interactions have been strongly supported by the experimental measurements designed to test and verify them.
InnateDB was used to generate a network of experimentally supported molecular interactions that have been annotated to occur directly between the DE genes and their encoded products.
InnateDB is one of the most comprehensive databases of all human and mouse experimentally supported molecular interactions (>300,000 interactions in July 2013) but also specifically includes annotation on more than 19,000 manually curated human and mouse innate immunity relevant interactions, many of which are not present in any other database (Lynn et al. 2010).
DASMI has been developed to support molecular interactions at different levels (Fig. 1).
Thus, currently, the definition of new pathways of molecular interactions is essential in supporting genetic observations.
A large degree of focus within the field has been placed on accurately and exhaustively extracting molecular interactions (MIs) from biomedical text, supported by collaborative events such as the BioCreative and BioNLP shared tasks (10, 11).
First, DNA binding site studies can be used to support direct molecular interactions between the upstream and downstream genes.
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