Novel lncRNAs are now being uncovered at an increasing rate, with molecular functions that include recruitment of histone-modifying complexes to chromatin [e.g. HOTAIR and HOTTIP (Rinn et al., 2007; Wang et al., 2011)] and modulation of transcription and splicing by molecular interaction with relevant factors [e.g. GAS5 and MALAT1 (Bernard et al., 2010; Kino et al., 2010)].
The pathological function of HS in the pathogenesis of inflammatory diseases is not fully understood; however, HS is known to regulate molecular and cellular interactions relevant to inflammation.
In conclusion, this investigation contributes to the development of new global insights into complex molecular interactions and processes relevant to human HF.
Using fluorescence resonance energy transfer (FRET) as a "molecular ruler" is a powerful approach for identifying biologically relevant molecular interactions with high spatiotemporal resolution.
Thus, our test case represents a typical situation faced by modellers; detailed quantitative measurements are in general not available for clinically relevant molecular interactions networks.
To further explore relevant molecular interactions, we used an integrated approach to understand differences in promoter methylation, miRNA expression, stem cell gene expression, and genotype data by tumor characteristics in a series of GCTs.
As a result, a major research effort has been directed at identifying the function of novel specific esophageal cancer related genes and elucidating the relevant molecular interactions of protein products which may play critical roles in ESCC.
36– 38 For more details about the interplay of autophagy and apoptosis, we refer the reader to the excellent review article by Marino et al. 39 From these facts we draw an "influence diagram", which summarizes our hypothesis about the most relevant molecular interactions between autophagy and apoptosis in mammalian cells.
Thus, quantifying the effects of aflibercept molecular interactions provides novel and clinically relevant insight and proposes new, testable hypotheses.
To a first approximation, then, modules of molecular interaction are computationally relevant units of functional phenotype.
