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The affinity of the interaction of RH5 with its receptor, and the receptor titer on the RBC may shed light on the identity of the receptor, and could also define the role of RH5 in the hierarchy of molecular interactions needed for successful invasion.
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Molecular interactions need to be taken into account to adequately model the complex behavior of biological systems.
Thus, our investigation suggests a role for ezrin and podoplanin in keratocystic odontogenic tumors and their molecular interactions need to be further explored in these kinds of tumors.
Although identification of the chemical domains responsible for this molecular interaction needs elucidation of the structure of this still-unsequenced mammalian phospholipase, the association of HER2 with an active PC-PLC isoform is apparently an important requirement for maintaining this receptor anchored to functional membrane domains.
Every second billions of high-precision molecular interactions take place in our cells without us needing to be even slightly aware of it.
There may be other molecular interactions that need to be explored further to address the discrepancies.
Like many other pharmacovigilance data analyses, our proposed associations between ADEs and high-dimensional drug interactions need further molecular experimental validation, and using a more stringent pharmacoepidemiological study design and alternative databases.
To adequately model complex behavior of biological systems one needs to take molecular interactions into account.
However, most of the existing simulation-based approaches resort to oversimplified models of molecular interactions, because detailed quantitative data, needed for a more realistic representation, were not always available.
Parameters such as rate constants of the molecular interactions are often unknown and need to be estimated from experimental data, e.g. by maximum likelihood estimation.
Further investigation is needed into the molecular interactions between CD163 and amyloid plaques, and whether these microglia co-express other receptors for Aβ.
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