As CD4 is the main cellular receptor used by HIV-1, knowledge of its molecular interactions is important for the understanding of viral infection strategies.
Our results confirm and extend the role of PDF in the molecular clock and more broadly demonstrate the utility of the novel live-imaging tools for investigating the molecular-neural interactions important for the operation of the circadian pacemaker circuit.
More broadly, our results establish the utility of the new live-imaging tools for the study of molecular-neural interactions important for the operation of the circadian pacemaker circuit.
Backert and colleagues [ 5] describe the molecular interaction of important adherence factors such as BabA/B, SabA, AlpA/B, OipA, and HopZ establishing a tight bacterial contact with host target cells necessary for colonization and pathogenesis of H. pylori.
Whether and how this genetic hierarchy regulating myofibrillogenesis translates into direct molecular interactions is an important avenue for further research.
As gene data rapidly accumulate, constructing the pathway of molecular interactions becomes increasingly important for entomological research.
The presence of disorder in human SIRT1 and the propensity of these proteins in promoting molecular interactions make it important to understand the underlying mechanisms of molecular recognition that reasonably should involve terminal segments.
Knowledge regarding the molecular architecture of STIM1 has grown considerably during the last years, and several structural domains within STIM1 have been reported to be required for the specific molecular interactions with other important players in Ca2+ signaling, such as Ca2+ channels and microtubules.
Many novel areas of research may involve physiologically important molecular interactions or functions that are still not well known or characterized, meaning that the available gene set collections may not be optimal for the interpretation of data from such studies.
Incorporation of molecular interactions is therefore an important area for further development, where greater fidelity with molecular systems that underlie disease mechanisms can be achieved.
