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PPARs are activated by fatty acids and eicosanoids and are also targets for antidyslipidemic drugs, but the molecular interactions governing ligand selectivity for specific subtypes are unclear due to the lack of a PPARα ligand binding domain structure.
The development of these 'epigenetic therapies' requires detailed knowledge of the molecular interactions governing chromatin regulation.
Specifically, the molecular interactions governing protein:protein and protein:DNA associations are not understood.
Second, the fact that non-specific binding, though minimal, results in CD34+ purity similar to that in whole blood, suggests that CD34+ enrichment in P-selectin tubes is the result of the specific molecular interactions governing cellular adhesion.
The molecular interactions governing this symbiosis, such as those involved in signaling between the bacteria and plant, or in penetrating the plant cell wall, are not well characterized, primarily because of the lack of genetic tools for generating Frankia mutants, but also because frankiae grow very slowly [ 1].
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These findings suggest that evolutionarily conserved molecular interactions govern chromatophore positioning — a proposal that should be investigated in the future.
In this context, the identification and characterization of the genes expressed during embryonic facial development will provide valuable insight into the molecular and cellular interactions governing this process.
As illustrated in Figure 1, environmental context strongly influences network operations regulating transcription, translation and posttranslational processes, so that restricting experimental measurement information to DNA sequence, mRNA expression or even protein expression will miss important aspects of the molecular components and interactions governing cell and tissue behavior.
Next, the Wyss scientists are planning to apply their DNA nanoswitch-enhanced miniature CFM to the investigation of select biomedically relevant and force-dependent molecular interactions such as protein interactions governing blood clotting or hearing.
An important step toward achieving this goal is to define the key molecular interactions that govern antibiotic resistance.
In this review we focus, in a morphologically integrated fashion, on the molecular interactions that govern the intricate cardiac design.
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